Mediterranean Citrus Compounds

D3 + K2 + Citrus
Bioflavonoids

Lichen-sourced D3, natto-fermented MK-7, and whole-peel citrus bioflavonoids from Valencia and Sicily. Nutraceutical-grade. Batch documented.

Explore Our Compounds
Mediterranean citrus and vitamins

From Brazilian Lab to Mediterranean Groves

Investshow began in Franca, São Paulo, where our research team studied the emerging literature on vitamin D3, K2, and citrus bioflavonoid combinations. What started as academic curiosity about this nutritional triad evolved into sourcing partnerships across two continents.

Our founders noticed that published research increasingly examined D3-K2-bioflavonoid combinations for bone mineral metabolism, cardiovascular support, and antioxidant function. The challenge was finding sources that matched the research specifications: lichen-derived D3, natto-fermented MK-7, and whole citrus bioflavonoids with proper standardization.

This led us to develop direct relationships with citrus processors in Valencia, Spain and Sicily, Italy, where generations of family operations had perfected whole-peel processing techniques that preserve the full bioflavonoid spectrum.

Today, Investshow operates from our Brazilian headquarters while maintaining sourcing partnerships across the Mediterranean citrus belt. Every batch combines the precision of laboratory science with the traditional knowledge of citrus cultivation passed down through generations.

Mediterranean Citrus Heritage Meets Modern Research

The citrus groves of Valencia and Sicily represent centuries of cultivation expertise. These regions produce oranges and lemons with exceptionally high bioflavonoid concentrations due to the Mediterranean climate, volcanic soil conditions, and traditional growing methods that prioritize fruit quality over yield.

Our Spanish and Italian processing partners use whole-peel methods that capture the complete bioflavonoid profile: hesperidin, naringenin, nobiletin, and diosmin. This differs from synthetic isolation methods that target individual compounds. Research suggests that these bioflavonoids work synergistically with vitamin C and may have enhanced bioavailability when consumed as part of their natural citrus matrix.

Each shipment from our Mediterranean partners includes detailed harvest documentation, soil analysis reports, and bioflavonoid concentration certificates. The processors provide HPLC standardization data for every batch, ensuring consistent compound levels that match published research specifications.

The Three Compound Strategy We Follow

Published research has identified vitamin D3, K2, and citrus bioflavonoids as a potentially synergistic combination. Each compound appears to support the others' bioavailability and function through different mechanisms.

Vitamin D3 from Lichen

Cholecalciferol sourced from lichen rather than lanolin, making it appropriate for vegetarian diets. Research consistently shows lichen-derived D3 effectively raises serum 25-hydroxyvitamin D levels, the accepted biomarker for vitamin D status.

K2 as MK-7 from Natto

Menaquinone-7 from traditional natto fermentation has the longest half-life among K2 forms and shows superior bioavailability in pharmacokinetic studies. Research indicates MK-7 activates vitamin K-dependent proteins more effectively than shorter-chain menaquinones.

Citrus Bioflavonoid Complex

Hesperidin, naringenin, nobiletin, and diosmin from whole citrus processing. Studies suggest these compounds support vitamin C absorption and provide antioxidant activity. The full-spectrum approach preserves the natural ratios found in citrus fruit.

From Sunny Groves to Laboratory Capsules

Our manufacturing process begins in Mediterranean citrus groves during peak harvest season. Spanish and Italian partners select fruit at optimal ripeness when bioflavonoid concentrations reach their highest levels. The whole-peel processing occurs within hours of harvest to preserve compound stability.

Lichen-sourced vitamin D3 comes from specialized cultivation facilities that grow lichen in controlled environments, ensuring consistent cholecalciferol production without animal-derived ingredients. The natto fermentation for our MK-7 follows traditional Japanese methods, using specific bacterial strains that produce the longest-chain menaquinone form.

All raw materials undergo identity testing, potency verification, and purity analysis before entering our Brazilian facility. The encapsulation process uses pharmaceutical-grade equipment in climate-controlled environments to maintain compound stability.

Each finished product batch receives comprehensive testing for potency, purity, and microbial safety before release. We maintain detailed documentation for every step from grove to capsule.

Current Product Offerings

D3 + K2 (MK-7) Daily Formula

D3 + K2 Formula

Vitamin D3 (cholecalciferol) from lichen at 5,000 IU, the form consistently shown in pharmacokinetic research to raise serum 25-hydroxyvitamin D levels. Vitamin K2 as MK-7 (menaquinone-7) from natto fermentation at 120mcg, the K2 form with the longest half-life and highest bone-specific protein activation data. The dosage combination based on published D3/K2 co-supplementation research. Lichen-sourced D3 is vegetarian-appropriate; natto-derived MK-7 is vegan-appropriate.

Citrus Bioflavonoid Complex with Vitamin C

Citrus Bioflavonoid Complex

Full-spectrum citrus bioflavonoid complex providing hesperidin (500mg standardized to 92%, from sweet orange peel), diosmin (300mg), nobiletin (50mg), and naringenin (100mg). Combined with Vitamin C from whole-food acerola cherry extract (400mg) and rosehip powder (200mg) for natural ascorbic acid with intact bioflavonoid co-factors. All citrus compounds sourced from Spanish and Italian whole-citrus processors. Full HPLC standardization certificates per batch.

Citrus Antioxidant Complex

Citrus Antioxidant Complex

A blend of citrus bioflavonoids (hesperidin 250mg, naringenin 100mg) with vitamin C (500mg as buffered ascorbate). These compounds work synergistically. Published research has studied bioflavonoid-vitamin C combinations for their enhanced antioxidant properties. 60 vegetarian capsules.

Research Literature We Study

Our product development follows published research on vitamin D3, K2, and citrus bioflavonoid interactions. Studies have examined how vitamin D3 and K2 work together in calcium metabolism, with D3 increasing calcium absorption and K2 directing calcium to bone tissue rather than soft tissues.

Citrus bioflavonoid research has focused on their antioxidant properties and potential enhancement of vitamin C bioavailability. Hesperidin studies have examined its role in supporting cardiovascular function, while naringenin research has investigated its antioxidant and anti-inflammatory properties.

Pharmacokinetic studies comparing different forms of vitamin D3 consistently show that cholecalciferol effectively raises serum 25-hydroxyvitamin D levels. Research on vitamin K2 forms demonstrates that MK-7 has superior bioavailability and longer half-life compared to shorter-chain menaquinones.

Clinical trials examining D3-K2 combinations have studied their effects on bone mineral density and cardiovascular markers. While individual responses vary, the research provides the scientific foundation for our formulation approach.

Mediterranean Climate and Compound Quality

The Mediterranean climate provides ideal conditions for citrus cultivation, with hot, dry summers and mild, wet winters that concentrate bioflavonoid production in citrus peels. Spanish Valencia oranges and Italian lemons grown in these conditions typically contain higher hesperidin and naringenin levels than citrus grown in other climates.

Volcanic soil in Sicily contributes additional mineral content that appears to enhance bioflavonoid synthesis in citrus trees. Soil analysis from our Italian suppliers shows elevated levels of potassium, magnesium, and trace minerals that research has linked to increased secondary metabolite production in citrus fruit.

Traditional cultivation methods in these regions avoid intensive agricultural practices that can reduce bioflavonoid concentrations. Our Spanish and Italian partners use minimal irrigation, allowing trees to develop deeper root systems that access natural soil nutrients.

Harvest timing plays a crucial role in bioflavonoid concentration. Our partners harvest citrus at peak ripeness when compound levels reach their maximum, then process the peels immediately to preserve compound stability and prevent degradation.

Get Citrus Nutrition Research Updates

Receive updates on new research findings about vitamin D3, K2, and citrus bioflavonoid combinations, plus information about product availability and Mediterranean sourcing updates.

Contact Our Brazilian Operations

Investshow operates from our headquarters in Franca, São Paulo, Brazil, where our research and customer service teams handle inquiries about our products, sourcing documentation, and research literature.

Our customer service team can provide detailed information about specific batch documentation, raw material certificates of analysis, and sourcing partner details. We maintain comprehensive records for all products and can assist with questions about ingredient sources, testing methods, and quality control procedures.

For technical questions about our products or to request specific documentation, contact our support team at [email protected] or +15614858937. We typically respond to inquiries within 24 hours during business days.

Our mailing address for correspondence and documentation requests is Rua Jose Gomes Moreira Filho 69, Franca, SP 14405394, Brazil. Written requests for batch documentation or quality control certificates should include the product name and batch number found on the product label.